Insulin For Alzheimer’s Disease

  by  |  February 2nd, 2009  |  Published in All, Brain & Psychology, Featured, Health


 |  Stumble |  Share on Facebook |  Tweet This | 

New research published today says that insulin, the hormone used to treat diabetes, might some day be useful for treating or preventing Alzheimer’s disease.

[If you cannot see the flash video below, you can click here for a high quality mp4 video.]

Interviewee: Bill Klein, Northwestern University
Produced by Sunita Reed and Brad Kloza– Edited by James Eagan
and Brad Kloza Copyright © ScienCentral, Inc

"Type 3" Diabetes?

Neuroscientist Bill Klein and colleagues at Northwestern University had previously discovered evidence that Alzheimer’s disease might actually be a form of diabetes of the brain. Prior studies by other researchers found that patients with Alzheimer’s disease had lower levels of insulin, and that their brains were insulin-resistant. Klein discovered that, in addition to the plaques and tangles in brains of those with Alzheimer’s, there were toxic proteins called ADDLs (pronounced "ADD-els").

Also on ScienCentral

In normal brains, insulin binds to sites on cells called receptors, triggering a series of events that allow memories to form. By studying rat brain cell cultures in the lab, Klein’s team discovered how ADDLs can interfere with the memory-formation process. When they added the ADDLs, they attached to their own receptors on the cell surface and caused the insulin receptors to disappear.

“Insulin in the brain is just not working,” explains Klein. Even though it’s there, it doesn’t have a place to park. Its receptors seem to be less responsive to the insulin. That’s the same thing that occurs in type 2 diabetes outside of the brain."

In the current study, Klein and his colleagues at the Federal University of Rio de Janeiro, Brazil, tried a strategy to protect the insulin receptors from damage. Before adding ADDLs, they flooded the brain cells with a high concentration of insulin. The insulin treatment blocked the ADDLs from attaching to the ADDL receptors and completely protected the insulin receptors.

“In brains, it is indeed a battle between which signaling pathway is the stronger… Insulin for the force, and ADDLs for the dark side,” Klein adds.

But the injected insulin used by many diabetics does not reach the brain, so Klein says specific drugs will need to be developed that selectively target the brain. He points out that such drugs would also avoid affecting insulin function in the body. Klein’s team will soon study these strategies in a mouse model of Alzheimer’s. But Klein says that he is also trying to find vaccines that target ADDLs and that his goal is to combine vaccines with ways to enhance insulin function.

PUBLICATION: The Proceedings of the National Academy of Sciences, February 2, 2009
AUTHORS: Fernanda De Felice, Marcelo Vieira, Theresa Bomfim, Helena Decker, Pauline Velasco, Mary P. Lambert, Kirsten L. Viola, Wei-Qin Zhao, Sergio Ferreira, and William Klein
RESEARCH FUNDED BY: American Health Assistance Foundation, Alzheimer’s Association, National Institutes of Health-National Institute on Aging; Howard Hughes Medical Institute, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/Brazil, and Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro and Human Frontier Science Program.

Elsewhere on the Web:


Alzheimer’s Disease

Mild Cognitive Impairment


 |  Stumble |  Share on Facebook |  Tweet This | 


Responses

  1. Gregg Zetzman says:

    February 2nd, 2009 at 8:15 pm (#)

    More funding, please

  2. Bill D. Johnston says:

    February 17th, 2009 at 11:15 am (#)

    I hope that this research proves to be true. It won’t help my father now, but perhaps it will help someone in the future.

  3. CinGx Treats and Prevents Type 3 Diabetes, Alzheimer’s | Products for Seniors says:

    March 16th, 2011 at 8:47 pm (#)

    [...] supplement, or used in a number of food and beverage products. For more information, visit and http://www.sciencentral.com/video/2009/02/02/insulin-for-alzheimers-disease/ Related Posts :Vision and Dental Insurance For Seniors Reverse Mortgages for Seniors not Favorable [...]

  4. cholesterol level control says:

    April 29th, 2011 at 7:58 pm (#)

    Hello Webmaster, commenters and everyone else !!! The weblog was completely implausible! Plenty of nice data and inspiration, each of which we all need!Preserve ‘em coming… you all do such a terrific job at such Ideas… can’t tell you how much I, for one appreciate all you do!

  5. LivingDiseaseFree.com says:

    August 16th, 2011 at 8:42 am (#)

    Amazingly, new studies are suggesting that the plaques associated with Alzheimer’s disease actually start in the liver and not in the brain which has completely altered scientists’ ideas about the disease.

  6. dental implants muncie in says:

    March 5th, 2013 at 1:00 am (#)

    I simply couldn’t go away your web site before suggesting that I extremely loved the standard info an individual provide on your visitors? Is going to be back frequently in order to check out new posts

  7. agate cameo says:

    March 22nd, 2013 at 4:06 pm (#)

    Pretty great post. I simply stumbled upon your blog and wished to say that I’ve really loved browsing your blog posts. After all I’ll be subscribing in your rss feed and I hope you write once more very soon!| agate cameo http://www.goldmemoriesforever.com

  8. tyflas says:

    March 22nd, 2013 at 4:31 pm (#)

    Hey there, I think your website might be having browser compatibility issues. When I look at your blog in Firefox, it looks fine but when opening in Internet Explorer, it has some overlapping. I just wanted to give you a quick heads up! Other then that, terrific blog!| tyflas http://www.takeload.com

  9. foto nunti says:

    March 23rd, 2013 at 2:40 am (#)

    Pretty! This has been an extremely wonderful article. Thank you for providing this information.| foto nunti http://madvideo.ro/fotograf-de-nunta/

  10. ProcurementinEast-Afri says:

    March 23rd, 2013 at 8:47 am (#)

    What’s up Dear, are you truly visiting this web page regularly, if so afterward you will absolutely obtain nice knowledge.| Procurement in East-Africa http://mj-resources.net

  11. pure garcinia cambogia says:

    March 23rd, 2013 at 9:01 am (#)

    I read this article completely about the comparison of latest and preceding technologies, it’s awesome article.| pure garcinia cambogia http://www.pure-garcinia-cambogia.org

  12. hochzeitsfotosMünchenw says:

    March 23rd, 2013 at 10:14 am (#)

    hey there and thank you for your information – I’ve certainly picked up something new from right here. I did however expertise a few technical points using this site, since I experienced to reload the site many times previous to I could get it to load properly. I had been wondering if your hosting is OK? Not that I’m complaining, but slow loading instances times will sometimes affect your placement in google and could damage your high quality score if ads and marketing with Adwords. Well I’m adding this RSS to my e-mail and could look out for a lot more of your respective exciting content. Make sure you update this again soon.| hochzeitsfotos München wedding photos munich http://www.fotostudioaugenblicke.de

  13. refinance car loan rates says:

    May 20th, 2013 at 12:07 am (#)

    I absolutely love your website.. Great colors & theme.

    Did you make this web site yourself? Please reply back as I’m hoping to create my own blog and want to learn where you got this from or what the theme is called. Kudos!

  14. wedding shoes wedges says:

    May 20th, 2013 at 1:31 pm (#)

    What a information of un-ambiguity and preserveness of
    valuable experience about unpredicted emotions.

    my blog wedding shoes wedges

  15. press release service says:

    May 21st, 2013 at 9:57 pm (#)

    Hello! Do you know when they make any plugins to safeguard against hackers?
    I’m kinda paranoid about losing every thing I’ve worked hard on.
    Any guidelines?

  16. garcinia cambogia extract says:

    June 28th, 2013 at 9:53 am (#)

    I do not even know how I ended up here, but I thought this post was great.
    I do not know who you are but definitely you are going to a famous blogger if you are not already ;)
    Cheers!

  17. memory supplements says:

    July 2nd, 2013 at 4:55 pm (#)

    So as opposed to walking at a constant tempo for say an hour, you’ll transform issues up by alternating short bursts of intense walking for say a minute followed by a recovery period with slower strolling just after every single intense time period. Just keep alternating for 20 minutes to begin and include time while you turn into additional match. You may use interval instruction with all phases with theprocera avh to enhance your final results.

    Also when you do any type of exercising it is actually strongly suggested that you simply drink tons of water ahead of through and just after to help keep your body effectively hydrated.

  18. Gold Coast removalist says:

    July 10th, 2013 at 12:19 am (#)

    The other day, while I was at work, my cousin stole my
    iphone and tested to see if it can survive a 40 foot drop, just so
    she can be a youtube sensation. My iPad is now broken and she has 83 views.
    I know this is entirely off topic but I had to share it
    with someone!

  19. Website Transfer says:

    July 10th, 2013 at 12:27 am (#)

    Simply wish to say your article is as amazing. The clearness in your submit is simply great and i can
    suppose you are knowledgeable in this subject. Well together with your permission let
    me to take hold of your feed to stay up
    to date with drawing close post. Thank you a million and please carry on
    the rewarding work.

  20. mobile app reviews says:

    July 18th, 2013 at 7:40 pm (#)

    What’s up, constantly i used to check blog posts here early in the morning, since i enjoy to find out more and more.

  21. vigrx xxl says:

    March 22nd, 2014 at 12:00 am (#)

    I’m really inspired with your writing talents as neatly as with the structure in your weblog.
    Is this a paid topic or did you customize it yourself?
    Either way keep up the nice quality writing, it is uncommon to look a nice weblog like this one these days..

  22. public liability insurance online quote says:

    April 18th, 2014 at 3:04 am (#)

    I am sure this article has touched all the internet viewers,
    its really really fastidious paragraph on building up new blog.

    my web blog: public liability insurance online quote

  23. supplements harmful says:

    August 16th, 2014 at 9:46 pm (#)

    Excellent post. I certainly appreciate this site.

    Continue the good work!

    My weblog: supplements harmful

  24. vigrx reviews says:

    September 4th, 2014 at 3:08 pm (#)

    Marvelous, what a web site it is! This website provides useful data to us, keep
    it up.

    Feel free to visit my page … vigrx reviews

  25. marine refrigerator leather repair huntington ny says:

    September 7th, 2014 at 5:43 pm (#)

    Furthermore, feeding live food is difficult as all live
    meals have a much higher risk in bringing bad bacteria or microorganisms
    that maybe harmful to your fish. Many times I have tried to avoid the most popular swims
    for this reason because this is where the fish will often feed most carefully and be most
    hard to catch. You will catch red fish, spotted sea trout, pompano, snook, mangrove snapper, Spanish mackerel, small
    black-tip sharks, small bonnet sharks, sheephead & in cooler
    weather the odd king mackerel.

    my webpage … marine refrigerator leather repair huntington ny

  26. website says:

    September 19th, 2015 at 7:06 pm (#)

    website

    Insulin For Alzheimer’s Disease | ScienCentral | Science Videos | Science News :: ScienCentral | Science Videos | Science News

Leave a Response


Archives


Clicky Web Analytics