Red Wine Aging Drug

  by  |  January 24th, 2008  |  Published in All, Health


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Could a pill that’s designed to treat Type 2 Diabetes also be the first anti-aging drug? As this ScienCentral News video explains, the pills are based on a substance in, of all things, red wine.

Anti-Aging Genes

The search for an anti-aging pill could soon pay off in new diabetes treatments. Pills being tested on people with diabetes activate the same gene as a beneficial compound found in red wine does, a gene identified by researchers as a key to controlling aging.

“A lot of metabolic illnesses actually are diseases of aging,” says Christoph Westphal, CEO of Sirtris Pharmaceuticals, which is developing and testing their new pills. “What’s new is, we’ve understood that the genes that control the aging process in fact can be targeted, developed into drugs to treat those diseases of aging. What’s very new is bringing these different worlds together, the world that was interested in diabetes on the one hand, with the world of science that was interested in understanding aging and how aging occurs.”

Decades of previous research in animals showed that severely restricting calorie intake lengthens lifespan in every animal species studied, including primates.

In recent years, scientists have zeroed in on the genes activated by caloric restriction, which turn out to improve metabolic function by affecting the energy centers of cells, the mitochondria.

A family of genes that make proteins called sirtuins have emerged as frontrunners.

Sirtris researchers screened thousands of small molecules for those that can activate the sirtuin genes. Their first candidate, which turns on the SIRT1 gene, is an enhanced version of the red wine compound resveratrol. They showed it can control diabetes in animals and are now testing it in people with diabetes.

“This is not science fiction anymore,” Westphal says. “We are actually talking about real drug candidates in human studies targeting diseases of aging by targeting the genes that control the aging process. This is not 20, 30, 40 years away. We believe actually we may be on the market within the next five to seven years.”

Sirtris founder, Harvard’s David Sinclair, who showed in 2006 that reseveratrol could reverse the complications of obesity and diabetes in animals, acknowledged taking resveratrol, resulting in major web attention like this.

But Westphal says taking resveratrol supplements might not do much for lifespan or diabetes. “Resveratrol, which is currently found as a nutraceutical supplement, we believe, cannot reach therapeutic levels,” he says. “You would have to take hundreds of pills a day, we believe, to have a therapeutic effect. That’s because native reserveratrol can’t reach your bloodstream. It’s not absorbed by your gut.”

So the company enhanced it to make it more bioavailable. They recently announced unpublished results of their early human trials of that drug, SRT-501 that they say demonstrated safety, as well as hinted at efficacy. “We reached statistical significance,” Westphal says, adding that they plan to publish the data, along with early results from additional trials, in scientific journals. They published their preclinical trial results in the journal Nature.

They found that, “You could treat diabetes in the three key models. These are animal models of diabetes where it’s very predictive when you see effects [such as] lowering blood sugar and improving insulin sensitivity, that you will see similar effects in human patients,” he says.

And as they reported in Nature, they’ve now discovered other molecules that, in animal tests are a thousand times more potent. “We showed that you could develop molecules that had the same activity, but at 1000th the dose,” says Westphal. “So these are the kind of things that you could imagine taking one small pill once a day.”

While longevity researchers have come to view aging itself as a host of diseases of failing metabolism, Westphal explains that they’re focusing on one disease of aging, diabetes, because the FDA doesn’t classify aging itself as a disease.

“Sirtris is focused on developing drugs that would be approved by the Food and Drug Administration, we’re very focused initially on developing drugs to treat diabetes,” he says. But since these genes have also been shown to stop other diseases of aging, like cancer and Alzheimer’s, he adds that the company is well aware of the possibilities.

“What’s particularly exciting is, when you target the genes that control the aging process, you seem to be able to treat all diseases of aging in a new and safe way. Diseases of aging include diabetes, Alzheimer’s, cancer, inflammation. So, if we’re right, this is actually potentially of profound importance for a number of the major killers of Western society,” says Westphal.

The company also has some competition. Elixir Pharmaceuticals, also based in Cambridge, is targeting the sirtuins and other genes for treating obesity and diabetes. And it may well turn out that existing drugs that already have the FDA seal of approval will turn out to extend lifespan.

This research was published in Nature, Nov. 29, 2007 and funded by Sirtis Pharmaceuticals.


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Responses

  1. Trevor Alfred says:

    October 27th, 2008 at 10:51 pm (#)

    Here is why i love Genesis Resveratrol. The World’s only Standardized Resveratrol & Ellagic Acid Drink. The Energy Health drink of the century, Anti Aging Properties – 30-70% life extension in laboratory tests Controls high blood pressure, Promotes healthy heart tissue, Lowers Bad Cholesterol, Increases Good Cholesterol Inhibits blood clots Prevents damage caused by lack of oxygen to brain and heart Preserves red blood cells Reduces risk of breast cancer Causes aptosis (death of cancer cells) Protects cells from free radical damage Lowers PSA levels in males; reduces the risk of prostate cancer Promotes Better Sleep Maintains younger looking skin Inhibits inflammation Speed up fat-burning within the cells Controls Blood Sugar lowering the risk of Diabetes Cleanses brain tissue of the amyloid plaque connected to Alzheimer’s Acts as hormone, gene and enzyme modulator Diminishes incidence of Acid Reflux Inhibits Ulcers Rejuvenates organs like Liver & Kidneys Anti-bacterial Anti-Fungal Slows down duplication of flu virusHere are some of the nutrients in the genesis PhytoPure™ 100% Juice Blend with Genesis ™ Herbal Infusion‡ Apple juice (reconstituted), whole fruit pomegranate extract, Aloe Vera juice (reconstituted) and whole fruit grape extract infused with barley grass, cinnamon bark, coriander leaf, coriander seed, cucumber, fig fruit, garlic bulb, juniper berry, leek, lentil, mulberry fruit, olive leaf, onion bulb, sweet almond and wheat grass Read More

  2. Anti Aging says:

    November 15th, 2008 at 3:37 am (#)

    Lowers Bad Cholesterol, Increases Good Cholesterol Inhibits blood clots Prevents damage caused by lack of oxygen to brain and heart Preserves red blood cells Reduces risk of breast cancer Causes aptosis (death of cancer cells) Protects cells from free radical damage Lowers PSA levels in males;

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    November 27th, 2008 at 1:21 am (#)

    Well, keep testing it untul you get the right version and then build a drug rehab center in each community and start helping people.

  4. Red Wine & Aging Update | ScienCentral | Science Videos | Science News says:

    December 9th, 2008 at 8:50 am (#)

    [...] have a new understanding of why a compound in red wine appears to retard aging in the same way as a very low-calorie diet. Writing in the journal, Cell, [...]

  5. Tim Lazaro says:

    January 16th, 2009 at 1:37 pm (#)

    Resveratrol strikes again. There is so much that we are learning about this ingredient in red wine.

    Please keep up the good work!

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    I’ve been drinking red wine for several months now, didn’t now it had anti aging benefits (just turned legal drinking age)

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    Doctor Sinclair has found this great miracle substance to expand our lives and cure us of aging and fat ailments. How cool is that?

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